Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.510 Therapeutic RGD Post-Transcriptional Regulation of Hepatic DDAH1 with TNF Blockade Leads to Improved eNOS Function and Reduced Portal Pressure In Cirrhotic Rats. 29263339

2017

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.540 Biomarker RGD Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic Expression of Vascular Endothelial Growth Factor and Angiogenesis in Chronic Liver Disease. 26627607

2016

Entrez Id: 64506
Gene Symbol: CPEB1
CPEB1
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.210 Biomarker RGD Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic Expression of Vascular Endothelial Growth Factor and Angiogenesis in Chronic Liver Disease. 26627607

2016

Entrez Id: 22846
Gene Symbol: VASH1
VASH1
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.210 ModifyingMutation RGD Disruption of negative feedback loop between vasohibin-1 and vascular endothelial growth factor decreases portal pressure, angiogenesis, and fibrosis in cirrhotic rats. 24390792

2014

Entrez Id: 9572
Gene Symbol: NR1D1
NR1D1
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Therapeutic RGD Novel role of nuclear receptor Rev-erbα in hepatic stellate cell activation: potential therapeutic target for liver injury. 24497272

2014

Entrez Id: 156
Gene Symbol: GRK2
GRK2
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Therapeutic RGD Glytan decreases portal pressure via mesentery vasoconstriction in portal hypertensive rats. 25469036

2014

Entrez Id: 2475
Gene Symbol: MTOR
MTOR
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Therapeutic RGD Rapamycin ameliorates inflammation and fibrosis in the early phase of cirrhotic portal hypertension in rats through inhibition of mTORC1 but not mTORC2. 24404143

2014

Entrez Id: 409
Gene Symbol: ARRB2
ARRB2
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Therapeutic RGD Reactive oxygen species are involved in regulating hypocontractility of mesenteric artery to norepinephrine in cirrhotic rats with portal hypertension. 24719556

2014

Entrez Id: 4804
Gene Symbol: NGFR
NGFR
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Biomarker RGD Blockage of the afferent sensitive pathway prevents sympathetic atrophy and hemodynamic alterations in rat portal hypertension. 22292477

2012

Entrez Id: 5176
Gene Symbol: SERPINF1
SERPINF1
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Biomarker RGD The expression of PEDF and VEGF in the gastric wall of prehepatic portal hypertensive rats. 22024088

2012

Entrez Id: 6376
Gene Symbol: CX3CL1
CX3CL1
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Biomarker RGD Gut-brain chemokine changes in portal hypertensive rats. 21347560

2011

Entrez Id: 1524
Gene Symbol: CX3CR1
CX3CR1
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Biomarker RGD Gut-brain chemokine changes in portal hypertensive rats. 21347560

2011

Entrez Id: 7054
Gene Symbol: TH
TH
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Biomarker RGD Atrophy of mesenteric sympathetic innervation may contribute to splanchnic vasodilation in rat portal hypertension. 19968782

2010

Entrez Id: 1621
Gene Symbol: DBH
DBH
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Biomarker RGD Atrophy of mesenteric sympathetic innervation may contribute to splanchnic vasodilation in rat portal hypertension. 19968782

2010

Entrez Id: 551
Gene Symbol: AVP
AVP
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.500 Biomarker RGD Restriction of drinking water abrogates splanchnic vasodilation and portal hypertension in portal vein-ligated rats. 18987488

2009

Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.220 Therapeutic RGD Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation. 19418582

2009

Entrez Id: 285
Gene Symbol: ANGPT2
ANGPT2
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.210 Biomarker RGD Apelin signaling modulates splanchnic angiogenesis and portosystemic collateral vessel formation in rats with portal hypertension. 19070926

2009

Entrez Id: 3320
Gene Symbol: HSP90AA1
HSP90AA1
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Biomarker RGD Increased heat-shock protein 90 expression contributes to impaired adaptive cytoprotection in the gastric mucosa of portal hypertensive rats. 19383083

2009

Entrez Id: 624
Gene Symbol: BDKRB2
BDKRB2
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Biomarker RGD Splanchnic hyposensitivity to glypressin in a hemorrhage-transfused common bile duct-ligated rat model of portal hypertension: role of nitric oxide and bradykinin. 19950773

2009

Entrez Id: 1644
Gene Symbol: DDC
DDC
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Biomarker RGD Down-regulation of genes related to the adrenergic system may contribute to splanchnic vasodilation in rat portal hypertension. 18457899

2008

Entrez Id: 1906
Gene Symbol: EDN1
EDN1
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.210 Biomarker RGD [Effect and mechanism of salvianolic acid B in attenuating elevated portal pressure in a rat model of portal hypertension induced by endothelin-1]. 17214938

2007

Entrez Id: 1909
Gene Symbol: EDNRA
EDNRA
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Biomarker RGD [Effect and mechanism of salvianolic acid B in attenuating elevated portal pressure in a rat model of portal hypertension induced by endothelin-1]. 17214938

2007

Entrez Id: 7077
Gene Symbol: TIMP2
TIMP2
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Biomarker RGD Modified synthetic siRNA targeting tissue inhibitor of metalloproteinase-2 inhibits hepatic fibrogenesis in rats. 17351970

2007

Entrez Id: 1910
Gene Symbol: EDNRB
EDNRB
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Biomarker RGD [Effect and mechanism of salvianolic acid B in attenuating elevated portal pressure in a rat model of portal hypertension induced by endothelin-1]. 17214938

2007

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0020541
Disease: Portal Hypertension
Portal Hypertension
0.200 Biomarker RGD Modifications produced by selective inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertension. 17876871

2007